Role of Sildenafil in Severe COVID-19 Pneumonia in Infancy-A Case Series

SARS-CoV-2 virus primarily affects the respiratory system, although other organ systems are also involved. Though pulmonary arterial hypertension (PAH) has been described in as a sequela of COVID pneumonia in adults, only a coincidental association between pre-existing PAH and SARS-CoV-2 infection in children has been reported. To our knowledge, severe COVID pneumonia-causing PAH in children, especially in infancy has not been reported yet. With the meteoric spread of the pandemic and rapid development of newer mutated variants, the timely discovery of new drugs is near impossible. The idea of repurposing existing drugs to treat COVID-19 is an attractive strategy, especially if they are already approved (for other indications) and have well-established safety profiles. Sildenafil specifically targets pulmonary vasodilation, endothelial function, and vascular remodelling. It hence has emerged as an effective first-line oral therapeutic agent for patients with symptomatic PAH in all age groups. We present a case series of four cases where Sildenafil has been repurposed for the treatment of PAH associated with severe COVID-19 pneumonia in infancy. Copyright © 2022 by author(s).

Unequal lives: a sociodemographic analysis of COVID-19 transmission and mortality in India.

OBJECTIVES: Existing socio-economic inequalities shape, in very particular and measurable ways, the differential impact that a disease has on different sections of the same society. This is particularly true of COVID-19, which has rapidly exhausted the public health system in India, and magnified the gradient of vulnerability in an underserved populace. Using publicly available data, we have aimed to deconstruct this gradient into individual variables of inequality and quantify their impact on the transmission and mortality outcomes of COVID-19 in India. STUDY DESIGN: Sociodemographic analysis. METHODS: We quantify doubling times and case fatality ratios for all districts in India, then correlate them to 20 variables of socio-economic vulnerability and demographic structure. Variables that exhibit persistent correlation are then analysed using multivariate beta regression models to validate their impact on COVID-19 outcomes in India. RESULTS: The transmission of COVID-19 in India is enhanced by the lack of access to indoor latrines, drainage facilities, electricity, and proximate sources of drinking water. Transmission is slowed by the presence of an elderly population. Fatality rates relate negatively to an area's medical infrastructure and the presence of a college-educated populace. CONCLUSIONS: An interactive matrix of social inequalities, cultural practices, and behavioural patterns determines the path of COVID-19 through a community. Specific variables exhibit patterns of persistent vulnerability; others indicate a resistance to infection and mortality. This body of evidence, when incorporated into policy design, may lead to localised, need-sensitive models of intervention, both for preventive measures and medical care.

Integrating “Impacts of Covid-19 pandemic on air quality” in STEM courses and internships for undergraduate students

Air pollution is a global public health concern and has led to millions of premature deaths worldwide. In overpopulated cities, particulate matter such PM2.5, nitrogen dioxide (NO2), and ozone (O3) in the troposphere have deleterious effects on human health leading to cardiovascular and respiratory diseases. The students in two undergraduate courses (Principles of Biology for Honors students and Ecology) and one graduate course (Teaching STEM at the K-12 schools) at the University of Maryland Eastern Shore;and summer-exchange undergraduate engineering interns learnt about the positive and negative effects of Covid-19 pandemic on air quality for some of the selected overpopulated cities in the world that witnessed lockdowns from March 2020 through spring 2021. The STEM students as well as the interns had the opportunity to learn how to analyze the real-time and historical air quality data from the Environmental Protection's Agency's centralized data system, AirNow, as well as from the Air Quality Open Data Platform (https://aqicn.org/data-platform/covid19) Worldwide Covid-19 dataset. For the above-mentioned courses, the materials pertaining to Covid-19 and air quality were taught in the form of modules (two for each course) with lectures;discussions and class debates;video materials;simulations with real-time data;and a project centering on that theme. The engineering students who worked as summer interns worked on analyzing data from five of the major cities in the world. Besides analyzing the effects of the pandemic on PM2.5, NO2, and O3 in the selected populated cities, the students also studied whether any correlations existed among the air quality parameters or not. The students' learning outcomes included honing content knowledge in atmospheric chemistry and physics of particulate matter;environmental sciences and engineering;public health and policies;research skills with respect to data analysis and problem-solving;as well as presentation and writing skills. The students and interns in the courses and internships also addressed and debated on the various issues of sustainability, which encompasses social, environmental, economic considerations along with policies. The crisis of the pandemic on climate change is dependent on the policies of the governments towards which directions the economies need to head. When the governments prioritize to shift from fossil fuels to cleaner energy such as wind, solar, geothermal, biofuels, then the mitigation efforts of climate change could come to fruition. It is anticipated that with more ongoing collaborations across disciplines, the authors will be able to permanently integrate these diverse components in other STEM courses such as Statistics for Engineers, Big Data Analytics, and enhance multidisciplinary learning for all majors. This integration of research findings in STEM courses is a reflection of the KDB (Know, Do, Be) framework, as the interns and the students honed their skills not only in content knowledge through inquiry, but felt responsible in taking action towards mitigation efforts of climate change. © American Society for Engineering Education, 2022

A 3D-printed, touch-activated, sanitizer dispensing device for reducing healthcare-acquired infections

Aim: We present a touch-activated, sanitizer dispensing (TSD) device, intended to be mounted on high-touch surfaces, that aims to reduce nosocomial infections. It disinfects the person's hand touching its surface while being self-sterilizing. Materials & methods: The TSD device consists of an array of 3D-printed, passive, miniaturized, mechanical valves that dispense a small amount of liquid sanitizer when touched. Its mechanical performance and disinfecting efficiency were quantified using simulations and experimental tests. Results & conclusion: The TSD device has a disinfecting efficiency comparable to the standard hand sanitizing approach, reducing the microbiological load by approximately 30-times. It can be easily mounted on high-touch surfaces in a healthcare setting and it is expected to greatly reduce the spread of nosocomial infections.

Perspectives of medical students on medical education services during the COVID-19 pandemic in India

Introduction: The COVID-19 pandemic had a disruptive effect on medical education services. Many medical schools curbed clinical interaction and replaced in-person classes with online methods. Baring a few review articles, research articles in this domain are scare. This study was done in the present context to understand the perspectives of the medical students on the different teaching methods adopted and the acceptability of those mechanisms from the view of the end-users is novel. Materials and Methods: This study was undertaken between 1 May 2020 to 15 May 2020 in 600-bed tertiary care teaching hospital in India having affiliation for both undergraduate and postgraduate medical teaching. A pre-structured questionnaire was randomly distributed to 500 students by sharing a link in the email addresses of the students. Data were entered and analysed in the Microsoft Excel 2010 using descriptive statistics. Results: So far as the different methods of online teaching are concerned, the Interactive online sessions were attended by 59.5% of the study respondents, 28.3% of the study respondents mentioned attending webinars while uploaded lectures were attended by 12.2% study respondents. 150 (57.3%) of the respondents mentioned that the online training sessions were equally effective as in-person training classes. However, a sizeable proportion of 90 (34.3%) respondents mentioned that the online training sessions were less effective. Conclusion: Though technology has been rapidly and innovatively used to ensure medical education services continue unhindered, it has thrown up major challenges. These challenges need to be addressed immediately if we need to reap its benefits in future. © IJCRR.